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I'm visiting one of the worlds 's so called zones es to out out wiits residents live longer healthier lives than average many of those in low melinda california as seven day adventice a religious group that really values health and community
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你服给我了
好
请你想哥这的一句话啊
Would you like from me to prepare your breakfast or yes please is that be lothly also what i can say already here looks very healthy
Embarrassed
We enjoy fruits and nuts and greins and all of this stuff we want to eat healthy
We want to exercise because my body is the temple of god
So if i stay strong and clear
Mind it up be of service living
This life is sented around
What the advantage referred to was the health message hehealy lisong is to refrain from rerasing unhealthy activities more family oriented lifestyle aside from that duty to protect physical health that exist here community spirit is strong
What i didn't realize was how important socialization is to your brain and without it
It seems to shrink and go away
And so the ability to just have heart opening
Brain opening conversations is very very very important
And that mental stimulation matters
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As we get older our brain shrink
We lose brain cells and brain connections
This can impact our memory and our attention spans
It doesn't happen to everyone equally though our bodies age
Our brain ages at different speeds based on different things
There are eighty seven year old
That are sharpers a wiand and part of gengenetics and part of its lifestyle
The life you lead informs your genetics
S in your genetics and expresses itself based on the interaction
You have with your environment
Which is why social interaction is so important
Social intereraction is basically exerciising your brain
As we start to understand more about how it works andages
Experts are taking advantage of the power of ai and big data
It helps them see patterns of how cogressitive decline can play out and indeed the disease process
When it comes to something like dementia
But also other sources and its andrea revio research is brain aging based on data from fifteen thousand brains
He's aiming to provide a better way of predicting decline
It's looking at a lot of different patterns related not only to shrking king of the brabut
Also if you see experties of the signal and intensity on these mrice scts
What sort of uses all there in this technology for helping with dimentia
So if shows diffediffeces or treeing between cognitively normal adults and patients with alzheimer's diatase
So where you see either red or blue those are areas
Where ageing is occurring in a different way in patients with alceimerers what sort of impact on that have on both diagnoses and etentially even treating ing alzeimeras
So if we can identify individuals who is brains
Our aging ing lot trefasor and estimaate their risk for disease a lot better
So if either clinicians can provide costom taylor treatment
So individuals themselves can implement lifestyle changes
I am a professional rejuvenation athlete
I love it take entrepreneur
Brian johnson son spending millions trying to turn back time on his body
I visited him last year to our earth 's extreme and sometimes controversial regime a fitness
Fasting a load of tablets
Tracking and treatments
And i'm back to see how it's going
What have you achieve
What's possible and what's breaving challenging hearing still remain something we can do much about heart health
We've made great strires in my cart of accularability
My bone mineral density
My strength
Can you told me through what you're looking at in your brain and had fikind of interventions you'll doing
And then reverse that biological age
The brain shrinks and changes over time
So you're looking at the actual brain
And then functionally you look at how it actually works ks then what can can do next
So we've ve one several things like clasher
When we spoke
I mentioned that i had i problems
Where my poshure was poror like and what actually do next
Yeah
Fifix it yeah and lessto my blefalo and so with bad poshure and had white matter hyper intensities
This is like a scaring for the brain
When i fixed my poshure
And i did it physical to therapy exercises and reduced my white matter hyperintencities by nine years i dramatically reduce my my poure
And by fixing my posture
What we have to remembers that if you do experiment on an individual
There's very different than experiment on a population that can be pure reviewed and replicated
Maybe though we can learn something from the animal world and one companies been researching ground sirrels like this one behind me to see what they're gaming from hibernation
They slowlow spend half the year going in doubt of a state of intense hibernation
Their body temperature drops and their metablic rate is turn down to just one percent of normal as they're leaving hibernation
They have this amazing adaptation
Where they're able to regrow these neurons
And they're able to have these uronal connections
Again biotech company former ers been tracking the the imimals aiming to develop drugs
To replicate these benefits in humans
One side of the coin is looking at alzheimermerdiseasase patients
And saying what's different about their proteins
Which genes are active
Are not active
And then we compare that to the opposing biology of the squirrel that we know
Can modify the protein in a good way and regrow the neurons
But those that trdifate into humans
Yes
Ninety percent of the protein or more looks exactly like the human protein spending six months a year on the ground isn't generally an option for us
But getting good sleep is crucial sleep is the single most effective thing that you can do each and every day to reset your brain and body health
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Your brain has a cleensing system
We knew that your body had once called the limmpthetic system
You've had a bad
We didn't think the brain had one
But it does
And it's called the glimphthetic system
Named after the gleal cells that make it up
It was specifically during sleep and during deep sleep
That this sort of you know power clends for the brain began to unfold
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Why is this relevant for alzheimer's
Because two of the pieces of a metabolic build up of this detroitus that was washed away by the glmpthetic system during sleep with things called bitter amaloid and tow protein
Which are two of the culprits underlying alzheimeras
You don't start to see the decline in your deep sleep
That is associated without zheieimer's risk
What your sixties or your seventies it begins in your late thirties
So what if i could shift from a model of late stage treatment to a model of middle life prevention
And could we start to help the brain at that middlife stage
我心里藏是你的手
Music is a big part of life here ir lolovlinda
And there could be some brain gains recent studies suggests that learning a music instrument or even singing throughout your life could benefit your brain health in later years
It's not only about staying shop though healthy happy aging is about the whole package mildrid was a doctor
She even set up a hospital in uganda
And was working in health care in low mellinda
You're one hundred and three on you yes
That's an incredibly age
How old you feel i'm getting like a warn out model tea
It's falling apart
How would you describe your quality of life at this point
Pretty useless i would never recommend and say okay you pick being old as the way you're quininy and july forget it
You've lived quite some life
And you've had to go through a lot to reach this age
You recommend living into year hundreds or not i don't think i'd recommend anything about life
And it's linth
I have tried to be heavy
And i've managed pretty well going from talking to brian johnson to someone who's one hundred and three made this all seem very real
We need to look after not just our bodies
But our minds
It's just a matter of how important being able to quantify
That is it's certainly going to make a difference
When it comes to research in the future
And the power of ai and big data is making a lot of possipossible
It's just right
Now there is no self ver bullet
The power of this computational biology and ai will be to help you understand your self over time
And what the things you do benefit you technologies helping us understand and predicts like never before we know better than ever
What we should be doing to look after ourselves
But perhaps milderage should have the last word
You absolutely need to be very careful
What we your diyad it's true
But i not done ned her
Any you've got into this and this and this and absolutely not touch this
She think it's more important to live
I think it's more important to live
It
