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Women are works of art on the outside as on they inside
I am a neuroscientist
And they focus on their inside
Especially on women's brains
There are many theories on how women's brains difer er man's brains
And i've been looking a brains for twenty years
And can guarantee that there is no such thing as a mender brain
Pink and blue barbe an lege
Those are all inventions
That have nothing to do with where brains are built
That said women's brains differ from men's brains in some respects and them here to talk about these differences
Because they actually matter for our health
For example
Women are more likely than men to be diagnosis with an anxiety disorder or depression
Not to mention on headaches and migraants
But also at the quarof my research
Women are more likely than men to have alzheimer's disease
Alzeimerous disease is the most common cause of dementia on the planet affects ting close to six million people in their united states alone
But almost two thirds of all these people are actually women so for every men suffering from alzeimer's
That are two women so
Why is that overall all is it age is in ice spin
What else could have been a few years ago
I launched the women's brain initially a wild connect medicine in new yorc city
Exactly to answer those questions in tonight
I'm here with some answers
So it turns out our brains age differently and menopause plays the key role here for women
Now most people think of the brain is some kind of black box isolafrom the rest of the body
But in reality
Our brain said in constant interaction with the rest of us in perhaps
Surprisingly the interactions with the rereproductive system
A crucial for brain aging in women
These interactions are mediated by our hormones
And we know that hormonmondiffer er between the genders
Men have motis stosterton
Women have more exstrogents
But what really matters here is that this hormones differ in their lan jevity menster stoster on doesn't run out until lid in life
Which is a slow low prepretty sysymptom free process
Of course women's right
Women's astrogenes on the other hand start fade in in midlife during menopause
Which is anything but synttom frame
We associate menopause with the overorities
But when women say that they're having hot
Fasshes my sweats in sommia memdy laughses depression anxiety
Those symptoms don't start in the orverorities
They start in the brain
Those are neurological symptoms were just not used to thinking about them as such
So why is that
Why are our brains impacted by menopause
Well first of all our brain and overorities are part of the noodle and the crerent system
As part of the system
The brain talks to the overorities
And the overorities talk back to the brain
Every day overlies as women
So the health of the overorities is linked to the health to the brain
In the other way around at the same time
Horrogts like exstrogen are not only involved in reproduction
But also in brain function and exsterrogeny particular or extradial is really key for energy production in the brain
When your cstlululevevel exstergen literally pushes neodles to bring glucals to make energy
If your exsterrogen is high
Your brain energy is high
When your exstrogen declines though your alodons start slowing down in age
Faster insteand is of showing that this process can even lead to the formation of ameeloid places or alzheimer's places
Which at a hallmark of alzheimer's disease
These effects are stronger in specific brain regions
Starting with the high posoonomous
Which is in charge of regulate in body temperature res
When astronan doesn't activate the high posoleomous
Correctly the brain cannot regulate body temperatures correctly
So this hot flashes their women get does the high posonomous
Then as the the brains
Them in charges asleep and wake
When exstrogen doesn't activate the brain stem could act me
We had trouble sleeping ing
It's the ammdalla
The emotional centre of the brain
Close to the heapo campus the memorial centre of the brain
When exstrogence levels eb in these regions we start getting mood swings perhaps
They forforget things
So this is the brain anonomy or menopause
If you will
But let me show you what an actual woman's brain can look like
So this is a kind of brain
Skcan called positive emissito
Tommogragraphy or pet it looks at brain energy levels
In this is what you want your brain to look like when you're in
You're for this really nice sim bright
Now this brain belongs to a woman who was forty three years old
When she was first scanned before manoppouse
And this is the same brain just eight years later after menopause
If we put inside by a sign
I think you can easily see how the bright yellow turan orange joomous purple
That's a thirty percent drop in brain energy levels
Now general this just doesn't seem to happen to a men of the same age in our stdies with hundreds of people
We show the middle age men usually have high brain energy levels for women
Brain energy usually fine before mopopuse
But then it gradually declines during the transition right
And this was found independent of age
It didn't matter that women were
Were fifty
Fifty
Ty ty ty
Mamatthered most was that they were in menopause
So of course
When it more research to confirm this
But it looks like women's pains in mdlife are more sensitive to hormonal aging than just trayde up chronological aging
It this is important information to have
Because so many women can feel these changes
So many of papatients said to meme that they feel like their mindplane tricks on them to put it mildly
So i really want to validate this
Because it's real
And they really want to clarify it
This is you so are not crazy
Thank you
It's too important
So many women are worried
That they might be lose in their minds right
But the truth is then your brain might be going into a transition or ease going into a transition
And it's time and support to adjust
Also if anyone is concerned
The middle age women might be under performers are just quickly
And that we look the connective performers got forickright
But if underthat
But we looked the connetive performance
And we found absolutely no differences between men and women before and after menopause and other studies confirmed this so basically we may be a tired right
But we are just as sharp get that anyway
Um that also said there is something else more serious
That deserves that attention
If you remember i mention that esterrogen declines could potentially promote the formation of emalo places or alzheimer's places
But there's another kind of brainscan that looks exactly at those places
And we used it to show the middle age men hardly have any which is great
But for women this quite a bit of an increase due in the transition to menopuse use
And they want to be really really clear
Here that not all women developed the places
And not all women with the places developed dementia
Having the places of risk factor
It is not in any way
A diagnosis especially at this stage
But still it's quite an insight to associate alzheimer's with manoppause
We think a manoppoas is belonged into middle age
And alzheimer's bebeongged into old age
But in reality manistand is including my yon't work
Has shown that alzheimer's disease starts when negative changes in the in in years
If not decades prior to clinical sysympoms
So so women it looks like this process starts in need life due in manoppause
Which is important information to have
Because it gives us a timeline to start looking for those changes so in terms of a timeline
是的 对的
Most women go through menopause in their early fifties
But they can be earlier
Often because of medical interventions and the common example is a historacomy and or an apheracommy
Which is the surgical removal of deudros and or the overorities and the forforununately that the evidence to having the udados and more so the overis removed prior to manoppouse codllates with the higher risk of dementia in women
And i know that this is upsetting news
And it's definitely depressing news
But we need to talk about it because most women are not aware of this caldulation and this since that very important and information to have
Also no one is suggested the women declined these procedures that they need them
The point here is that we really need to better understand what happens to our brains as we go through manoppouse natural or medical
And how to protect our brains in the process
So how do we do that
How do we protect our brains
Should we take hormonds
That's a fair question
It's a good question in the short test
Possible answer
Right now is that whoermonotherapy can be helpful to alleviate a number of symptoms i hart flashes
But there's not cutingly recommended for dementia prevention
And many of us are working on testing different formulations in different dosages
In different thailwlands
And hopefully all this work will lead to a change in recommendations in the future
Meanwhile there are other things that we can do today to support our hormonts and their effects on the brain that do not require medications
But do require taking a good look at our lifestyle
That's because the foods we eat how much exercise we get
How much sleep we get or dog get how much stress we have in our lies
Those are all things that can actually impact our horromends for better and for worse food for example
There are many diet out there
But studies have shown that the mediativion diet in particular is supportive a women's health women on this diet have a much lower riscle committee decline of depression
Heheart sesease of stroke andle cancer
And they also have fewer heart flashes with interesting about this diet is that is quite reaching foods that contain exstrogents in the form of fghal extrogents or extrogents from plans that act like mild exstrgits in our bodies
Some fighal astrogents have been linked to a possible riiskle cancer
But not the ones in these diet which are safe especially from flax seeds
Sesemseds
Ds seappricts
Lilegus in the number of fruits
And for some good news
Dark chocolate contains vital extrogents
Too so diet is one way to gain extrogts
But it's just as important to avoid things to supppress our exstrrogents instead especially exstress stress can literally steal your exstrogents
And that's because courtisal which is the main stress hormonon works in balance with their exstrogents
So a courtisal goes up
Your exstersal goes down
Your courtisal goes
Your exstrogents go back up
So reducing stress is really important
So doesn't n't just help your day
It
It helpps your brain
对对对对对
So these are just a few things that we can do to support our brain
And there are more
But the important thing here is that changing
The way we understand the female brain really changes
The way that we care for it
And the way that we frame women's health
And the more women
The man is information the sooner will be able to break the taboozthat on manopuse use
And also come up with solutions actually work not just for alzheimer's disease before women's brain health as a whole brain health is women's health
Thank you
Thank thank you 啊thank you
